Do you have to have the genes for depression in order to get depressed?

We are not sure of that yet. Some people prefer to believe that their depression is a one-time event triggered by an outside tragedy, and it may be. However, it is unlikely that circumstances alone cause unipolar major depression most people who are exposed to severe circumstances do not become depressed. And often the first depressive episode is followed by others through the years that have either minor triggers or none at all.