Marplan (generic name: isocarboxazid) is an MAOI that has been around for many years but gradually fell out of use. Now a pharmaceutical company has taken Marplan under its wing and is trying to bring it back.
Marplan works the same way as other MAOIs, by blocking the enzyme that destroys serotonin, norepinephrine, and dopamine. It also has similar side effects. Doctors who swear by Marplan say that it is less sedating and less likely to cause postural hypotension than Nardil. It is less stimulating than Parnate. Marplan comes in 10-milligram tablets and is typically started at one tablet twice daily.
One big reservation doctors have about Marplan is the danger of prescribing an antidepressant that might go off the market and become unavailable. If Marplan becomes more popular again, it will likely come into more widespread use.