Anafranil (generic name: clomipramine) was developed in the 1960s by the Swiss manufacturer Geigy, now known as Novartis. It helps increase brain serotonin at low doses and norepinephrine at moderate doses. Anafranil may be especially helpful in the treatment of obsessive-compulsive disorder (OCD) or panic disorder. It comes in 25, 50, and 75-milligram capsules and is usually started at 25 milligrams at bedtime, gradually increasing to 75-225 milligrams. It stays in the body four to six days after you stop taking it.
Anafranil works very well at decreasing depression, but because of its strong side effects dry mouth, dry eyes, sedation, constipation, and weight gain many patients do not like it. There are other tricyclic antidepressants, like Tofranil, that are just as effective but have fewer side effects. Interestingly, clomipramine is sold by veterinarians under the name Clomicalm, as a treatment for obsessive habits like skin licking and tail chasing.