The process through which a mitochondrion, an energy-producing structure within a cell, carries the molecules it needs for its metabolic functions. The mitochondrial electron transport chain is significantly less active in the brain cells (neurons) of people with Parkinson’s disease, impairing mitochondrial metabolism and causing mitochondrial dysfunction. This lack of activity shortchanges the cell of adenosine triphosphate (ATP), its primary fuel source, and proteins that it needs to carry out its functions, setting in motion a sequence of events that ultimately results in cumulative cell damage, which causes disease.
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